Selecting an appropriate counterion for a drug is essential for enhancing its solubility and bioavailability. Meglumine (N-methyl-D-glucosamine) is a commonly used counterion that helps improve the solubility of pharmaceutical compounds. It is an amino sugar derived from sorbitol and has a pKa value of approximately 9.6.
| Melting point | 129-131.5 °C (lit.) |
| alpha | -16.5 º (c=10, H2O, on dry sub) |
| Boiling point | 331.88°C (rough estimate) |
| density | 1.2669 (rough estimate) |
| refractive index | -16.5 ° (C=2, H2O) |
| RTECS | LZ4295770 |
| storage temp. | 2-8°C |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| pka | pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) |
| color | White to almost white |
| PH | 11 (10g/l, H2O, 20℃) |
| optical activity | [α]20/D 16.5±0.5°, c = 2% in H2O |
| Water Solubility | 100 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 14,6078 |
| BRN | 385906 |
| InChIKey | MBBZMMPHUWSWHV-VZFHVOOUSA-N |
| LogP | -3.370 (est) |
| NIST Chemistry Reference | N-methylglucamine(6284-40-8) |
| EPA Substance Registry System | Meglumine (6284-40-8) |
| Risk Statements | 36/37/38 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| F | 3-10-23 |
| Autoignition Temperature | ~662 °F |
| TSCA | Yes |
| HS Code | 29221980 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
Product Application of 1-Deoxy-1-(methylamino)-D-glucitol CAS#6284-40-8
As a cosolvent and surfactant for contrast agents.
Inventory 2-3 working days New production 7-10 working days
