Products Description of 1H-Indol-3-yl(2,2,3,3-tetramethylcyclopropyl)methanone
1H-Indol-3-yl(2,2,3,3-tetramethylcyclopropyl)methanone is a well-defined organic synthesis intermediate with a distinct molecular structure. It appears as an off-white to yellow crystalline solid, with a density of 1.099 ± 0.06 g/cm³ and a boiling point of 375.0 ± 15.0°C.
The compound exhibits good solubility in several commonly used organic solvents, with solubilities of 50 mg/mL in DMF, 33 mg/mL in DMSO, and 17 mg/mL in ethanol. It is primarily used as a building block in the development of novel drug molecules and has broad applications in the pharmaceutical and fine chemical industries.
Key Physical & Chemical Properties
| Property | Specification |
|---|---|
| Chemical Formula | C₁₆H₁₉NO |
| Appearance | Off-white to pale solid (typical) |
| Solubility | Soluble in organic solvents |
| Functional Groups | Indole + cyclopropyl ketone |
| Grades | Research / synthesis grade |
Main Applications
Organic Synthesis
Serves as an intermediate for constructing substituted indoles and aryl-cyclopropyl compounds.
The ketone group offers a convenient handle for reduction, amination, and C–C coupling steps.
Structure–Activity Research
Functions as a scaffold for building analogue libraries to study how structural changes affect biological activity.
Widely referenced in medicinal and pharmacological research on indole-based candidates.
Fine Chemicals
Precursor for specialty heterocyclic and carbonyl-functional molecules.
Useful in assembling fused or conjugated ring systems via classic indole chemistry.
Pharmaceutical Research
Building block for early-stage medicinal chemistry and hit-to-lead optimization.
Suitable as an analytical reference standard for R&D method development.
