Trifluoroacetamide CAS#354-38-1 Product Description
Trifluoroacetamide is an organic compound with characteristic physical and chemical properties that make it useful in specialized chemical synthesis. It has a reported melting point of approximately 72–75°C and a boiling point of around 162–164°C. The compound exhibits good solubility in water, ethanol, ether, and various polar organic solvents, allowing it to be considered for different reaction systems and formulation requirements. As an amide-containing compound, it displays characteristic amide-related chemical behavior. Furthermore, the presence of the trifluoromethyl (–CF₃) group influences its electronic properties and chemical reactivity, contributing to its distinctive performance in organic chemistry. Depending on the reaction conditions and synthetic route, trifluoroacetamide-related chemistry can be utilized in acylation processes and in protecting-group strategies, making it relevant to the preparation and modification of organic compounds.
Trifluoroacetamide CAS#354-38-1 Chemical Properties
| Melting point | 65-70 °C (lit.) |
| Boiling point | 162.5 °C (lit.) |
| Density | 1.4176 (estimate) |
| Bulk density | 960kg/m3 |
| Fp | 162-164°C |
| Storage temp | Store below +30°C |
| Solubility | 460 g/L (20°C) |
| Pka | 12.33±0.50(Predicted) |
| Form | Crystalline Powder or Crystals |
| Color | White to pale yellow or beige |
| PH | 3.6 (460g/l, H2O, 23℃) |
| Water Solubility | 460 g/L (20 ºC) |
| BRN | 1753625 |
| InChIKey | NRKYWOKHZRQRJR-UHFFFAOYSA-N |
| LogP | 0.725 at 23℃ and pH4.83 |
| Dissociation constant | 0 at 23℃ |
| CAS DataBase Reference | 354-38-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, 2,2,2-trifluoro-(354-38-1) |
| EPA Substance Registry System | Acetamide, 2,2,2-trifluoro- (354-38-1) |
Trifluoroacetamide CAS#354-38-1 Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39 |
| RIDADR | 1759 |
| WGK Germany | 3 |
| Hazard Note | Harmful/Irritant |
| TSCA | T |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29241900 |
Trifluoroacetamide CAS#354-38-1 Product Application
2,2,2-Trifluoroacetamide is a useful reagent in organic synthesis and can serve as an alternative to conventional reagents in the Gabriel-type preparation of primary amines from alkyl halides. The process typically involves N-alkylation of the trifluoroacetamide, followed by hydrolysis to remove the readily cleaved trifluoroacetyl group and release the corresponding primary amine. In addition, this compound can support N-alkylation reactions under phase-transfer catalysis conditions, offering flexibility in the introduction of alkyl substituents. By selecting appropriate reaction conditions and alkylating agents, sequential alkylation strategies can be employed to prepare a range of nitrogen-containing organic compounds, making 2,2,2-trifluoroacetamide a valuable intermediate for synthetic and fine chemical applications.
