2-Bromo-5-Hydroxypyrazine CAS#374063-92-0 Product Description
2-Bromo-5-hydroxypyrazine (CAS No. 374063-92-0) is a brominated pyrazine derivative with the molecular formula C₄H₃BrN₂O and a molecular weight of 174.983 g/mol. It is also known by several alternative names, including 5-bromo-2(1H)-pyrazinone and 2-hydroxy-5-bromopyrazine in Chinese nomenclature, while its commonly used English synonym is 5-Bromo-2(1H)-pyrazinone.
Under normal conditions, 2-Bromo-5-hydroxypyrazine typically appears as a white to light brown crystalline powder. Its reported physical and chemical properties include a density of 1.9 ± 0.1 g/cm³, a melting point of approximately 115°C with decomposition, and a boiling point of 444.0 ± 40.0°C at 760 mmHg. Its vapor pressure is reported as 0.0 ± 1.1 mmHg at 25°C, indicating very low volatility under the specified conditions.
Structurally, this compound consists of a pyrazine heterocyclic ring containing two nitrogen atoms, together with a bromine substituent and a hydroxyl group. It can also exhibit the corresponding pyrazinone tautomeric form, which accounts for its alternative name, 5-bromo-2(1H)-pyrazinone. The presence of these functional groups makes it a potentially useful building block for further chemical transformations and molecular derivatization. Owing to its brominated heterocyclic structure, 2-Bromo-5-hydroxypyrazine is of interest in organic synthesis, medicinal chemistry research, and the development of pharmaceutical intermediates.
2-Bromo-5-Hydroxypyrazine CAS#374063-92-0 Chemical Properties
| Melting point | 115-119°C |
| Density | 2.00±0.1 g/cm3(Predicted) |
| Storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| Pka | 10.02±0.40(Predicted) |
| Form | Crystalline Powder |
| Color | White to light brown |
2-Bromo-5-Hydroxypyrazine CAS#374063-92-0 Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| WGK Germany | 1 |
| HS Code | 29339900 |
2-Bromo-5-Hydroxypyrazine CAS#374063-92-0 Product Application
According to literature reports, 2-Bromo-5-hydroxypyrazine can also be used as a starting material or functional component in the preparation of graphite electrodes modified with CeO₂-ZrO₂-NiO and pyrazine-based materials. Such modified electrodes combine the electrochemical properties of metal oxide components with the functional characteristics of pyrazine-containing structures, offering potential applications in electrochemical research and electrode material development. This further highlights the potential versatility of 2-Bromo-5-hydroxypyrazine in materials-related research, in addition to its applications in organic synthesis and pharmaceutical intermediate development.
