2-Chloro-3-Methylpyrazine CAS#95-58-9 Product Description
2-Chloro-3-methylpyrazine is a halogenated pyrazine derivative that serves as a versatile building block in organic and pharmaceutical synthesis. The chlorine substituent attached to the pyrazine ring provides a reactive site for further chemical modification and substitution reactions, enabling the preparation of a variety of structurally diverse medicinal compounds. It is particularly valuable as a pharmaceutical intermediate in the synthesis of macrocyclic urea-based kinase inhibitors, making it useful in medicinal chemistry research, drug discovery, and the development of novel bioactive molecules.

2-Chloro-3-Methylpyrazine CAS#95-58-9 Chemical Properties
| Boiling point | 80 °C(Press: 27 Torr) |
| Density | 1.234g/ml |
| Storage temp | under inert gas (nitrogen or Argon) at 2-8°C |
| Pka | -0.31±0.10(Predicted) |
| Form | Liquid |
| Color | Colorless |
| LogP | 1.058 (est) |
| CAS DataBase Reference | 95-58-9(CAS DataBase Reference) |
| EPA Substance Registry System | Pyrazine, 2-chloro-3-methyl- (95-58-9) |
2-Chloro-3-Methylpyrazine CAS#95-58-9 Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| TSCA | Yes |
| HS Code | 2933119000 |
2-Chloro-3-Methylpyrazine CAS#95-58-9 Product Application
2-Chloro-3-methylpyrazine is primarily used as an important intermediate in organic synthesis and pharmaceutical research. Its chlorinated pyrazine structure provides a versatile reactive site for further chemical modification, making it useful in the preparation of various substituted pyrazine derivatives and nitrogen-containing heterocyclic compounds. It is also utilized in medicinal chemistry research and pharmaceutical development, particularly as a building block for the synthesis of biologically active molecules and kinase inhibitor candidates. Additionally, the compound finds applications in laboratory research, synthetic chemistry, and the development of novel pharmaceutical intermediates.
