6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride CAS#2328-12-3 Product Description
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (CAS No. 2328-12-3) is an isoquinoline-derived organic compound belonging to the class of nitrogen-containing heterocyclic compounds and plant-associated alkaloids. It has been reported to occur naturally in the cactus species Backebergia militaris. The compound typically appears as white to slightly beige, glossy flakes or a crystalline powder and is primarily utilized as an important intermediate in pharmaceutical synthesis and chemical research.
In terms of its physicochemical properties, this compound exhibits a melting point ranging from 260 to 265°C. It demonstrates good solubility in polar solvents, including water and methanol, while showing limited solubility in non-polar solvents such as diethyl ether and petroleum ether. It can also dissolve in a 1N sodium hydroxide solution prepared in methanol at concentrations of up to 25 mg/mL, producing a clear, colorless solution. These characteristic physical and solubility properties make it a useful compound for laboratory research, organic synthesis, and pharmaceutical intermediate development.
6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride CAS#2328-12-3 Chemical Properties
| Melting point | 260-265 °C(lit.) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble25mg/mL, clear, colorless (1N NaOH in methanol) |
| form | Shiny Flakes or Crystalline Powder |
| color | White to slightly beige |
| BRN | 3634126 |
| InChIKey | SHOWAGCIRTUYNA-UHFFFAOYSA-N |
| CAS DataBase Reference | 2328-12-3(CAS DataBase Reference) |
6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride CAS#2328-12-3 Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | NX5017980 |
| HazardClass | IRRITANT |
| HS Code | 29334900 |
| Toxicity | mouse,LD50,intraperitoneal,272mg/kg (272mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Yakugaku Zasshi. Journal of Pharmacy. Vol. 88, Pg. 1197, 1968. |
6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinoline Hydrochloride CAS#2328-12-3 Product Application
It is widely employed as a versatile starting material and synthetic building block for the preparation of structurally diverse and more complex isoquinoline- and quinolizidine-based derivatives. Its chemical structure provides a useful foundation for further molecular modifications and the development of various nitrogen-containing heterocyclic compounds, supporting its applications in organic synthesis, medicinal chemistry, and pharmaceutical research.
