Potassium Clavulanate CAS#61177-45-5 Product Description
Potassium Clavulanate, also referred to as clavulanic acid potassium salt (CAS No. 61177-45-5), is a potent β-lactamase inhibitor extensively utilized in the pharmaceutical industry to improve the efficacy of antibiotic treatments against bacterial infections.
Serving as a key pharmaceutical intermediate and active ingredient in the production of advanced antibiotic formulations, Potassium Clavulanate is manufactured in accordance with stringent quality standards and performance specifications to meet the demands of modern pharmaceutical production processes.
Potassium Clavulanate CAS#61177-45-5 Chemical Properties
| English Name | Potassium clavulanate |
| English Synonyms | CLAVULANATE POTASSIUM;CLAVULANIC ACID POTASSIUM;CLAVULANIC ACID POTASSIUM SALT;CLAVULA NTE POTASSIUM;MM 1415;Potassium Clavulanat;Clavulanate;4-Oxa-1-azabicyclo3.2.0heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, monopotassium salt, (2R,3Z,5R) |
| CAS Number | 61177-45-5 |
| Molecular Formula | C8H10KNO5 |
| Molecular Weight | 239.27 |
| EINECS Number | 262-640-9 |
| Melting point | >1600C (dec) |
| Specific rotation | +55~+60° |
| Storage conditions | Inert atmosphere,2-8°C |
| Solubility | Easily soluble in water, slightly soluble in ethanol (96%), and very slightly soluble in acetone. |
| Form | Solid |
| Color | Light brown to brown |
| Main applications | agriculture clinical environmental forensics and toxicology pharmaceutical (small molecule) |
| InChI | InChl=1/C8H9NO5.K.H/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/b4-1-/t6-,7 -/s3 |
| InChIKey | ABVRVIZBZKUTMK-JSYANWSFSA-M |
| SMILES | C([C@H]1/CV/O[C@]2([H])CC(=O)N12)=C/CO)(=O)O.[KH] [&1:1,4,r |
Potassium Clavulanate CAS#61177-45-5 Product Application
Potassium Clavulanate exhibits limited intrinsic antibacterial activity and is primarily used as a β-lactamase inhibitor. When administered in combination with amoxicillin, it inhibits the β-lactamase enzymes produced by resistant bacteria, protecting amoxicillin from enzymatic degradation and helping maintain its antibacterial effectiveness.
Active Pharmaceutical Ingredient (API) for Human Medicine (Main Application): Primarily incorporated into amoxicillin and potassium clavulanate combination products, including tablets, oral dry suspensions, and injectable powders. These formulations are used to treat a broad range of bacterial infections caused by β-lactamase-producing microorganisms, including infections of the respiratory tract, ear, nose and throat (ENT), urogenital tract, skin and soft tissues, intra-abdominal region, bones, and joints. They may also be used for the prevention of surgical site infections where clinically indicated.
Active Ingredient in Veterinary Pharmaceuticals: Applied in veterinary amoxicillin-clavulanate formulations for the management of bacterial infections in livestock, poultry, and companion animals. Its applications also include the treatment of mastitis in dairy cattle.
Reagent for Scientific Research: Used in microbiological antimicrobial resistance testing and pharmaceutical research, particularly in studies investigating β-lactamase activity and antibiotic resistance mechanisms.
