Trimethoxymethane

Versatile Chemical Intermediate: Widely used as a reagent in organic synthesis.

Methylation and Protection Chemistry: Useful in selected reactions involving methylation and functional-group transformations.

Moisture-Sensitive Reactivity: Reacts with water, making moisture control important during storage and use.

Synthesis Applications: Suitable for laboratory and industrial chemical synthesis.

Consistent Quality: Available in different purity grades according to supplier specifications.

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Product Description

Trimethoxymethane, commonly known as trimethyl orthoformate (TMOF) or methyl orthoformate, is an organic compound with the molecular formula C₄H₁₀O₃ and a molecular weight of approximately 106.12 g/mol. It is commonly used as a reagent and chemical intermediate in organic synthesis.

CID 9005 - PubChem+1

Trimethyl Orthoformate CAS 149-73-5

Trimethoxymethane Chemical Properties

Melting point 

-53 °C

Boiling point 

101-102 °C(lit.)

density 

0.97 g/mL at 25 °C(lit.)

vapor density 

3.67 (vs air)

vapor pressure 

23.5 mm Hg ( 20 °C)

refractive index 

n20/D 1.379(lit.)

Fp 

60 °F

storage temp. 

Store below +30°C.

solubility 

Miscible with ether, alcohol and benzene.

form 

Liquid

color 

Clear colorless

explosive limit

1.4-44.6%(V)

Water Solubility 

10 g/L (hydrolysis)

Sensitive 

Moisture Sensitive

Merck 

14,6884

BRN 

969215

InChIKey

PYOKUURKVVELLB-UHFFFAOYSA-N

LogP

-0.03-0.09 at 20℃

CAS DataBase Reference

149-73-5(CAS DataBase Reference)

NIST Chemistry Reference

Methane, trimethoxy-(149-73-5)

EPA Substance Registry System

Trimethoxymethane (149-73-5)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36

Safety Statements 

9-16-26-29

RIDADR 

UN 3272 3/PG 2

WGK Germany 

1

RTECS 

RM6650000

Autoignition Temperature

255 °C

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29159080

Hazardous Substances Data

149-73-5(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 3130 mg/kg

Safety and Storage

Highly flammable liquid and vapor. Keep away from heat, sparks, and open flames.

May cause serious eye irritation and respiratory irritation.

Handle in a well-ventilated area with suitable chemical-resistant gloves and eye protection.

Moisture-sensitive; keep the container tightly sealed and protect it from water.

Store in a cool, dry, well-ventilated area according to the supplier's SDS.

Follow applicable regulations for chemical handling, transport, and disposal.

Trimethyl Orthoformate CAS 149-73-5

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