Product Description
Trimethoxymethane, commonly known as trimethyl orthoformate (TMOF) or methyl orthoformate, is an organic compound with the molecular formula C₄H₁₀O₃ and a molecular weight of approximately 106.12 g/mol. It is commonly used as a reagent and chemical intermediate in organic synthesis.
CID 9005 - PubChem+1

Trimethoxymethane Chemical Properties
Melting point | -53 °C |
Boiling point | 101-102 °C(lit.) |
density | 0.97 g/mL at 25 °C(lit.) |
vapor density | 3.67 (vs air) |
vapor pressure | 23.5 mm Hg ( 20 °C) |
refractive index | n20/D 1.379(lit.) |
Fp | 60 °F |
storage temp. | Store below +30°C. |
solubility | Miscible with ether, alcohol and benzene. |
form | Liquid |
color | Clear colorless |
explosive limit | 1.4-44.6%(V) |
Water Solubility | 10 g/L (hydrolysis) |
Sensitive | Moisture Sensitive |
Merck | 14,6884 |
BRN | 969215 |
InChIKey | PYOKUURKVVELLB-UHFFFAOYSA-N |
LogP | -0.03-0.09 at 20℃ |
CAS DataBase Reference | 149-73-5(CAS DataBase Reference) |
NIST Chemistry Reference | Methane, trimethoxy-(149-73-5) |
EPA Substance Registry System | Trimethoxymethane (149-73-5) |
Safety Information
Hazard Codes | F,Xi |
Risk Statements | 11-36 |
Safety Statements | 9-16-26-29 |
RIDADR | UN 3272 3/PG 2 |
WGK Germany | 1 |
RTECS | RM6650000 |
Autoignition Temperature | 255 °C |
TSCA | Yes |
HazardClass | 3 |
PackingGroup | II |
HS Code | 29159080 |
Hazardous Substances Data | 149-73-5(Hazardous Substances Data) |
Toxicity | LD50 orally in Rabbit: 3130 mg/kg |
Safety and Storage
Highly flammable liquid and vapor. Keep away from heat, sparks, and open flames.
May cause serious eye irritation and respiratory irritation.
Handle in a well-ventilated area with suitable chemical-resistant gloves and eye protection.
Moisture-sensitive; keep the container tightly sealed and protect it from water.
Store in a cool, dry, well-ventilated area according to the supplier's SDS.
Follow applicable regulations for chemical handling, transport, and disposal.
