Product Description
Guaifenesin (CAS 93-14-1, 3-(2-methoxyphenoxy)-1,2-propanediol), also called guaiacol glyceryl ether, is a white to off-white crystalline powder widely used as an expectorant in over-the-counter cough and cold preparations. It is a well-tolerated, non-sedating mucolytic that thins and loosens phlegm in the respiratory tract.
Key features:
White to off-white crystalline powder, bitter taste.
Well-established expectorant with long clinical history.
Non-sedating, compatible with antihistamines and decongestants.
Good solubility in water and alcohol for liquid formulations.
High-purity grade meeting pharmacopeia standards (USP/EP/CP).
Stable in solid dosage forms and stable in liquid syrups.
Product Parameters
| Item | Specification |
|---|---|
| Product Name | Guaifenesin |
| CAS No. | 93-14-1 |
| EINECS No. | 202-234-7 |
| Molecular Formula | C₁₀H₁₄O₄ |
| Molecular Weight | 198.22 |
| Appearance | White to off-white crystalline powder |
| Purity (assay) | ≥ 98.5% – 101.0% |
| Melting Point | 79 – 83 °C |
| Loss on Drying | ≤ 0.5% |
| Residue on Ignition | ≤ 0.1% |
| Heavy Metals | ≤ 10 ppm |
| Solubility | Soluble in water and alcohol |
| Compliance | USP / EP / CP grade |
| Packaging | 25 kg fiber drum / double PE bag |
Product Application
Guaifenesin is a well-established active pharmaceutical ingredient mainly used as an expectorant in cough, cold and upper-respiratory products.
In OTC cough and cold medicines, it is formulated into tablets, caplets, syrups and extended-release suspensions. It works by irritating the gastric mucosa reflexively to increase respiratory tract fluid secretion, thinning mucus and making coughs more productive. It is commonly combined with dextromethorphan, pseudoephedrine, phenylephrine and antihistamines in multi-symptom cold products.
In prescription and clinical use, it is included in expectorant formulations for bronchitis, pharyngitis and other conditions with thick, difficult-to-clear sputum.
In veterinary and wellness products, it is used in equine and companion-animal respiratory supplements and in dietary supplements marketed for respiratory comfort.
