As an essential aliphatic amino acid, L-leucine is a fundamental component present across a wide variety of proteins. In combination with L-isoleucine and L-valine, it makes up the branched-chain amino acid (BCAA) group. Additionally, L-leucine and D-leucine represent a pair of enantiomers.
L-Leucine Chemical Properties
| Melting point | >300 °C (lit.) |
| alpha | 15.4 º (c=4, 6N HCl) |
| Boiling point | 122-134 °C(Press: 2-3 Torr) |
| bulk density | 300-400kg/m3 |
| density | 1,293 g/cm3 |
| vapor pressure | <1 hPa (20 °C) |
| refractive index | 1.4630 (estimate) |
| FEMA | 3297 | L-LEUCINE |
| Fp | 145-148°C |
| storage temp. | 2-8°C |
| solubility | 1 M HCl: 50 mg/mL |
| form | powder |
| pka | 2.328(at 25℃) |
| color | White to Off-white |
| Odor | at 100.00?%. odorless |
| PH | 5.5-6.5 (20g/l, H2O, 20℃) |
| biological source | plant |
| Optical Rotation | [α]20/D +15.5°, c = 2 in 6 M HCl |
| Water Solubility | 22.4 g/L (20 C) |
| λmax | λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05 |
| JECFA Number | 1423 |
| Sublimation | 145-148 ºC |
| Merck | 14,5451 |
| BRN | 1721722 |
| Stability: | Stability Moisture and light sensitive. Incompatible with strong oxidising agents. |
| LogP | 0.80 |
| CAS DataBase Reference | 61-90-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Leucine(61-90-5) |
| EPA Substance Registry System | L-Leucine (61-90-5) |
Safety Information
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | OH2850000 |
| TSCA | Yes |
| HS Code | 29224995 |
| Hazardous Substances Data | 61-90-5(Hazardous Substances Data) |
Amino acid-based pharmaceuticals serve as vital components in amino acid infusions and compound amino acid formulas. They play a key role in the diagnosis and clinical management of various pediatric conditions, including idiopathic hyperglycemia, glucose metabolic disorders, biliary liver disease with impaired secretion, anemia, toxic exposures, muscular dystrophy, poliomyelitis, neuritis, and psychiatric conditions.
