Idebenone CAS#58186-27-9 Product Description
Idebenone is a synthetic short-chain benzoquinone analogue of Coenzyme Q10. It appears as orange to orange-yellow crystalline powder, with potent antioxidant activity and good cell membrane permeability. It can scavenge free radicals, inhibit lipid peroxidation, protect mitochondrial function and boost ATP generation. Widely applied in pharmaceutical raw materials, dietary supplements and high-end anti-aging cosmetic actives for skin anti-oxidation, anti-wrinkle and soothing.
Its core functions:
Powerful antioxidant: eliminates reactive oxygen species, suppresses lipid peroxidation, protects mitochondrial membrane from oxidative damage;
Mitochondrial energy regulator: mediates electron transfer in respiratory chain, facilitates ATP synthesis;
Pharma API: approved for Leber’s Hereditary Optic Neuropathy (LHON) treatment; also studied for neurological and mitochondrial disorders;
Cosmetic active: premium anti-aging ingredient, reduces oxidative stress on skin, improves dullness, fine lines and photoaging;
Nutraceutical raw material for mitochondrial and cognitive support formulations.
Idebenone CAS#58186-27-9 Chemical Properties
| Melting point | 52-550C |
| Boiling point | 497.3±45.0 °C(Predicted) |
| density | 1.08±0.1 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | Solid |
| pka | 15.20±0.10(Predicted) |
| color | Orange |
| Merck | 14,4888 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3 |
| InChIKey | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| SMILES | C1(=O)C(OC)=C(OC)C(=O)C(C)=C1CCCCCCCCCCO |
| LogP | 3.490 (est) |
| CAS DataBase Reference | 58186-27-9(CAS DataBase Reference) |
Idebenone CAS#58186-27-9 Safety Information
| Hazard Codes | Xi |
| WGK Germany | 3 |
| RTECS | GU5290000 |
| HS Code | 2933399990 |
Idebenone CAS#58186-27-9 Product Application
Pharmaceutical Active Ingredient (API)
Idebenone is used in the treatment of Leber’s Hereditary Optic Neuropathy (LHON) and has also been explored for its potential role in supporting brain function and addressing cognitive impairment following cerebrovascular diseases and brain injuries. Additionally, it is investigated for applications in Friedreich’s ataxia and other mitochondrial and neurological disorders.Cosmetic Active Ingredient
Recognized as a premium anti-ageing ingredient, idebenone provides antioxidant benefits by helping neutralize free radicals and combat oxidative stress. It is used in skincare formulations to address photoaging, minimize the appearance of fine lines, improve dull-looking skin, and support skin soothing and repair. Common applications include anti-ageing serums, facial creams, eye creams, and skin-repair lotions.Dietary Supplement and Nutraceutical Ingredient
Idebenone serves as a mitochondrial antioxidant ingredient in nutraceutical formulations. It is incorporated into capsules and tablets designed to support cognitive health, cellular energy metabolism, antioxidant activity, and cardiovascular wellness.Research and Development Material
Idebenone is utilized as a laboratory research material for investigating mitochondrial biology, neuroprotective mechanisms, and antioxidant activity, supporting scientific studies and pharmaceutical research and development.
