2-Lodothiophene

Heterocyclic Structure: Contains a sulfur-containing five-membered thiophene ring.

Iodine Functional Group: The iodine substituent provides a useful site for further chemical modification.

Organic Synthesis Intermediate: Suitable for specialty organic synthesis applications.

Cross-Coupling Applications: Used as a starting material in palladium-catalyzed coupling chemistry.

Research Versatility: Relevant to the development of functional thiophene derivatives.

Fine Chemical Applications: Suitable for laboratory research and specialty chemical development.

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2-Lodothiophene CAS#3437-95-4 Chemical Properties

Melting point 

-40 °C (lit.)

Boiling point 

73 °C/15 mmHg (lit.)

density 

1.902 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.651(lit.)

Fp 

160 °F

storage temp. 

2-8°C

form 

Liquid

Specific Gravity

1.902

color 

Clear yellow-green to red-brown

Sensitive 

Light Sensitive

BRN 

104666

InChIKey

ROIMNSWDOJCBFR-UHFFFAOYSA-N

CAS DataBase Reference

3437-95-4(CAS DataBase Reference)

NIST Chemistry Reference

Thiophene, 2-iodo-(3437-95-4)

EPA Substance Registry System

Thiophene, 2-iodo- (3437-95-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-37/38-41-43-20/21/22-36/37/38

Safety Statements 

26-36/37/39-36/37-27

WGK Germany 

3

F 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29349990

Product Overview

2-Iodothiophene is a halogenated heterocyclic organic compound consisting of a thiophene ring substituted with an iodine atom at the 2-position. Its molecular structure combines the aromatic properties of thiophene with the chemical reactivity of the carbon-iodine bond.

It is an important building block in organic synthesis and is commonly used in the preparation of substituted thiophenes and other sulfur-containing organic compounds. Its iodine functional group makes it suitable for various carbon-carbon bond-forming reactions, including palladium-catalyzed cross-coupling reactions.

Product Manufacturing Process

Commercial production generally involves the preparation of iodinated thiophene derivatives through controlled halogenation or related organic synthesis processes, followed by separation, purification, and quality control. Specific manufacturing methods depend on the supplier's process and product specifications.

Main Applications

Organic synthesis intermediates

Thiophene derivative preparation

Pharmaceutical and medicinal chemistry research

Palladium-catalyzed cross-coupling reactions

Functional organic material research

Specialty heterocyclic compound development

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