Product Overview
Pyrazine is an aromatic heterocyclic organic compound with the molecular formula C₄H₄N₂ and a molecular weight of 80.09 g/mol. Also known as 1,4-diazine or p-diazine, it features a six-membered aromatic ring containing two nitrogen atoms positioned opposite each other. This distinctive molecular structure makes Pyrazine an important member of the diazine family and a useful building block in organic and heterocyclic chemistry.
Pyrazine is generally supplied as a white crystalline solid and has a characteristic strong odor often described as roasted, nutty, or corn-like. It has a melting point of approximately 54–56°C and a boiling point around 115–118°C. The compound is soluble in water and many organic solvents, supporting its use in different laboratory and industrial processes.
Pyrazine is relevant to flavor and fragrance chemistry because pyrazine compounds are associated with characteristic roasted and toasted aroma profiles. It is also used as a research chemical and as a starting material for preparing substituted pyrazine derivatives. Its defined chemical structure and versatile reactivity make it valuable in fine chemical synthesis, heterocyclic chemistry, and specialty ingredient development.
Pyrazine Chemical Properties
Melting point | 50-56 °C (lit.) |
Boiling point | 115-116 °C (lit.) |
density | 1.031 g/mL at 25 °C (lit.) |
refractive index | 1.5235 |
FEMA | 4015 | PYRAZINE |
Fp | 132 °F |
storage temp. | Store below +30°C. |
solubility | SOLUBLE |
pka | 0.65(at 27℃) |
form | Crystals |
color | White |
Specific Gravity | 1.031 |
Odor | at 0.10 % in propylene glycol. pungent sweet corn like roasted hazelnut barly |
Odor Type | nutty |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
JECFA Number | 951 |
Merck | 14,7957 |
BRN | 103905 |
Dielectric constant | 2.7999999999999998 |
Stability: | Stable. Highly flammable. Incompatible with acids, oxidizing agents. |
LogP | -0.26 |
CAS DataBase Reference | 290-37-9(CAS DataBase Reference) |
NIST Chemistry Reference | Pyrazine(290-37-9) |
EPA Substance Registry System | Pyrazine (290-37-9) |
Safety and Storage
Pyrazine should be handled in accordance with the applicable Safety Data Sheet (SDS) and relevant workplace chemical safety requirements. Avoid unnecessary contact with the substance and prevent dust or vapor from accumulating in the working environment. Use appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, and suitable protective clothing. Work in a well-ventilated area or under local exhaust ventilation, particularly when transferring, weighing, or handling the material in larger quantities.
Avoid inhalation of vapors or dust and prevent contact with eyes and skin. Do not eat, drink, or smoke in areas where the chemical is handled. Wash hands thoroughly after handling and remove contaminated clothing before reuse. In the event of accidental exposure, follow the first-aid instructions provided in the product-specific SDS and seek medical advice when necessary.
Store Pyrazine in a tightly sealed, clearly labeled container in a cool, dry, and well-ventilated location. Keep it away from excessive heat, direct sunlight, incompatible substances, and sources of ignition. Containers should remain properly closed when not in use to reduce exposure and prevent contamination. Storage conditions, handling precautions, and disposal procedures should always follow the supplier's SDS and local regulations
