4-Amino-2-chloropyridineCAS#14432-12-3
This product appears as white to pale‑yellow crystalline solid with melting point of 89‑91℃. It is slightly soluble in water, soluble in organic solvents such as methanol and DMSO, and stable under normal sealed storage conditions, while incompatible with strong oxidizing agents.
As a high‑value pyridine‑series fine‑chemical intermediate, 4‑Amino‑2‑chloropyridine features two active functional groups: amino group and chlorine atom on pyridine ring, which can undergo acylation, alkylation and nucleophilic substitution reactions for further derivatization.
It is a key building‑block raw material for synthesizing forchlorfenuron (KT‑30), a high‑activity plant growth regulator. Besides agrochemicals, it is widely applied in pharmaceutical API synthesis, dye intermediate preparation and organic synthetic research. It can be used to produce kinase inhibitors, anti‑inflammatory and antimicrobial pharmaceutical molecules via cross‑coupling chemical reactions.
4-Amino-2-chloropyridine Chemical Properties
| Melting point | 90-94 °C(lit.) |
| Boiling point | 153°C 5mm |
| density | 1.2417 (rough estimate) |
| refractive index | 1.5110 (estimate) |
| Fp | 153°C/5mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.73±0.30(Predicted) |
| form | Crystalline Powder |
| color | Light yellow |
| Water Solubility | Slightly soluble in water. |
| BRN | 108671 |
| InChIKey | BLBDTBCGPHPIJK-UHFFFAOYSA-N |
| CAS DataBase Reference | 14432-12-3(CAS DataBase Reference) |
