2-Hydroxy-3-trifluoromethylpyridineCAS#22245-83-6

  • High purity ≥98%, low moisture and ash, stable batch consistency for fluorinated fine chemical synthesis

  • Unique fluorinated heterocyclic scaffold with hydroxyl and trifluoromethyl groups; CF₃ group improves metabolic stability and lipophilicity of target molecules

  • Excellent regioselectivity in C-H activation and cross-coupling reactions, widely used as ligand for transition metal catalysis

  • White to pale yellow crystalline solid, good solubility in common organic solvents, easy for feeding and reaction control

  • Premium building block for pharmaceutical APIs, agrochemical fungicides/herbicides and medicinal chemistry research

  • Supports lab trial, pilot and bulk commercial supply; COA, MSDS, TDS and full export documents available

  • Flexible packaging, moisture-proof sealed packing to avoid degradation during storage and overseas shipment

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Products Description

2-Hydroxy-3-(trifluoromethyl)pyridine is an important pyridine derivative widely utilized as a chemical intermediate in various industries. It plays a significant role in organic synthesis and is commonly used in the development and production of pharmaceutical compounds, agrochemicals, and other fine chemicals. Its unique chemical structure and properties make it a valuable building block for applications in the chemical, pharmaceutical, and pesticide industries.

Product Name:

2-Hydroxy-3-trifluoromethylpyridine

Synonyms:

2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE;3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE;3-(TRIFLUOROMETHYL)-2-PYRIDONE;BUTTPARK 24\01-66;3-(Trifluoromethyl)pyridin-2-one;3-Trifluoromethyl-pyridin-2-ol;2-Hydroxy-3-(trifluoromethyl)pyridine 97%;2-Hydroxy-3-(trifluoromethyl)pyridine97%

CAS:

22245-83-6

MF:

C6H4F3NO

MW:

163.1

EINECS:

671-273-7

Product Categories:

Fluorine series;blocks;FluoroCompounds;Pyridines;Pyridine

Mol File:

22245-83-6.mol

 

Chemical Properties

Melting point 

150-153°C

Boiling point 

223.7±40.0 °C(Predicted)

density 

1.398±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder to crystal

pka

9.67±0.10(Predicted)

color 

White to Almost white

InChI

InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11)

InChIKey

JHDCDEHVUADNKQ-UHFFFAOYSA-N

SMILES

C1(=O)NC=CC=C1C(F)(F)F

LogP

0.71 at 25℃

CAS DataBase Reference

22245-83-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn,T

Risk Statements 

36/37/38-65-20/21/22-20/21-36-25

Safety Statements 

26-36/37/39-36-45

RIDADR 

UN2811

HazardClass 

IRRITANT

HS Code 

29333990

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