6-Bromo-1-Chloroisoquinoline CAS#205055-63-6 Product Description
1-Chloro-6-bromoisoquinoline is a halogen-substituted nitrogen-containing heterocyclic compound belonging to the haloisoquinoline family. Under normal ambient temperature and pressure conditions, it typically occurs as a pale-yellow to dark-yellow solid powder. The compound exhibits notable fluorescence properties and weak basic characteristics due to its nitrogen-containing isoquinoline ring structure. It is insoluble in water but displays limited solubility in certain alcoholic organic solvents. Its predicted boiling point is approximately 349.5 ± 22.0 °C, with a reported density of 1.673 g/cm³. Featuring both chlorine and bromine substituents on the isoquinoline framework, this compound provides opportunities for further chemical functionalization and serves as a potentially useful building block in heterocyclic chemistry, organic synthesis, and pharmaceutical research.
6-Bromo-1-Chloroisoquinoline CAS#205055-63-6 Chemical Properties
| Boiling point | 349.5±22.0 °C(Predicted) |
| density | 1.673 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 1.48±0.38(Predicted) |
| form | powder |
| color | Light yellow to yellow |
6-Bromo-1-Chloroisoquinoline CAS#205055-63-6 Safety Information
| Hazard Codes | T |
| Risk Statements | 25-38-41 |
| Safety Statements | 26-45 |
| RIDADR | UN2811 |
| HS Code | 2933499090 |
6-Bromo-1-Chloroisoquinoline CAS#205055-63-6 Product Application
1. Pharmaceutical Intermediates
Can be used as a synthetic intermediate for isoquinoline-based pharmaceutical candidate molecules.
Suitable for the construction of nitrogen-containing heterocyclic compounds with potential biological activities.
Can be used in the design and synthesis of novel pharmaceutical candidate molecules.
Serves as a basic building block for the structural optimization and derivative development of complex pharmaceutical molecules.
2. Medicinal Chemistry Research
Can be used in the design of pharmaceutical candidate molecules containing an isoquinoline structure.
Serves as a synthetic precursor for benzimidazole and other nitrogen-containing heterocyclic derivatives.
Suitable for research into compounds with potential Smoothened (SMO) receptor antagonist activity.
Can be applied in structure-activity relationship (SAR) studies of novel small-molecule compounds.
Previous studies have reported the use of this compound as a starting material for the synthesis of phenylimidazole derivatives with Smoothened antagonist activity.
Reference: CAS DataBase
3. Fine Chemical Synthesis
Can be used in the synthesis of various halogenated isoquinoline derivatives.
Serves as an important organic synthesis building block for nitrogen-containing fused heterocyclic compounds.
Its bromine and chlorine substituents provide different sites for cross-coupling and substitution reactions.
Suitable for the development of customized chemicals, specialty organic intermediates and high-value fine chemicals.
4. Functional Heterocyclic Compound Research
Can be used in the design and synthesis of novel isoquinoline derivatives.
Suitable for the structural modification of nitrogen-containing aromatic heterocyclic molecules.
Can be applied in the development of complex heterocyclic molecules and polysubstituted aromatic compounds.
Suitable for organic synthesis, medicinal chemistry and functional molecule research.
