2-Amino-5-Bromopyrazine CAS#59489-71-3 Product Description
2-Amino-5-bromopyrazine, also known as 5-Bromo-2-aminopyrazine, is a brominated nitrogen-containing heterocyclic compound widely used as an intermediate in organic synthesis and pharmaceutical research. Its molecular formula is C₄H₄BrN₃, with a molecular weight of 174.00 g/mol, CAS Registry Number 59489-71-3, and MDL Number MFCD00235015. Featuring a pyrazine ring substituted with an amino group and a bromine atom, this compound offers versatile chemical reactivity and serves as a valuable building block for the synthesis of various heterocyclic derivatives and other functional organic molecules.
Under normal conditions, 2-Amino-5-bromopyrazine typically appears as a brown, needle-shaped crystalline solid. Its reported physical and chemical properties include a density of 1.8 ± 0.1 g/cm³, a melting point ranging from 113 to 117°C, and a boiling point of 274.2 ± 35.0°C at 760 mmHg. Regarding its solubility, the compound is soluble in methanol, making it suitable for certain laboratory synthesis, dissolution, and purification procedures.
For proper storage and handling, 2-Amino-5-bromopyrazine should be kept in a tightly sealed container in a cool, dry environment. Contact with water should be avoided to help maintain product quality and stability during storage. Appropriate laboratory handling and storage precautions should also be followed.
Owing to its distinctive molecular structure and reactive functional groups, 2-Amino-5-bromopyrazine is a useful synthetic intermediate in heterocyclic chemistry, medicinal chemistry research, and the preparation of specialized organic compounds. The bromine substituent provides a potential site for further chemical transformations, while the amino group offers additional opportunities for molecular functionalization and derivatization.
2-Amino-5-Bromopyrazine CAS#59489-71-3 Chemical Properties
| Melting point | 113-117 °C (lit.) |
| Boiling point | 274.2±35.0 °C(Predicted) |
| density | 1.844±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Ethanol, Ethyl Acetate, Methanol |
| form | Brown Needles |
| pka | 1.66±0.10(Predicted) |
| color | Light yellow to Brown |
| InChIKey | KRRTXVSBTPCDOS-UHFFFAOYSA-N |
| CAS DataBase Reference | 59489-71-3(CAS DataBase Reference) |
2-Amino-5-Bromopyrazine CAS#59489-71-3 Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/38-43-44-36/37/38-20/21/22 |
| Safety Statements | 26-37/39-45-36/37/39-22-36/ |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29339900 |
2-Amino-5-Bromopyrazine CAS#59489-71-3 Product Application
2-Amino-5-bromopyrazine is an important brominated heterocyclic compound widely utilized as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a versatile building block for the preparation of various pyrazine derivatives, heterocyclic compounds, and other specialized organic molecules. Its molecular structure, featuring an amino group and a reactive bromine substituent on the pyrazine ring, provides opportunities for further chemical modification and functionalization, making it valuable in the synthesis of complex compounds and pharmaceutical intermediates. The compound is primarily used in laboratory research and development (R&D), medicinal chemistry studies, and various chemical and pharmaceutical manufacturing processes. Owing to its distinctive structural features and synthetic versatility, 2-Amino-5-bromopyrazine plays a useful role in heterocyclic chemistry, pharmaceutical research, and the development of specialty chemicals.
