2-Chloro-6-Aminopyrazine CAS#33332-28-4 Product Description
2-Amino-6-chloropyrazine (CAS Registry No. 33332-28-4) is a disubstituted nitrogen-containing heterocyclic compound with the molecular formula C₄H₄ClN₃ and a molecular weight of 129.55 g/mol. It is an important pyrazine derivative widely used as a synthetic building block in pharmaceutical research and organic synthesis, particularly for the preparation of A₂B adenosine receptor antagonists and various other biologically active compounds. Its pyrazine ring, incorporating amino and chloro substituents, provides versatile reactive sites for further chemical modification and molecular functionalization, making it a valuable intermediate in medicinal chemistry and drug discovery.
Under normal conditions, 2-Amino-6-chloropyrazine typically appears as a colorless to grayish-white solid. Its reported physical and chemical properties include a density of 1.4 ± 0.1 g/cm³, a melting point of 150–152°C, a boiling point of 282.8 ± 35.0°C, and a flash point of 124.8 ± 25.9°C. Regarding its solubility, the compound is slightly soluble in water but readily dissolves in hot methanol, making it suitable for certain laboratory preparation, purification, and synthetic procedures.
From a structural perspective, the amino group and chlorine atom attached to the pyrazine ring provide opportunities for various substitution and derivatization reactions. These characteristics make 2-Amino-6-chloropyrazine a useful starting material for the synthesis of structurally diverse heterocyclic molecules and pharmaceutical intermediates. Owing to its distinctive chemical structure and synthetic versatility, it has applications in medicinal chemistry, pharmaceutical development, and the preparation of specialized bioactive compounds.
2-Chloro-6-Aminopyrazine CAS#33332-28-4 Chemical Properties
| Melting point | 150-152°C |
| Boiling point | 282.8±35.0 °C(Predicted) |
| density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| form | Solid |
| pka | 0.89±0.10(Predicted) |
| color | Purple |
| LogP | 0.95 |
| CAS DataBase Reference | 33332-28-4(CAS DataBase Reference) |
| EPA Substance Registry System | 2-Amino-6-chloropyrazine (33332-28-4) |
2-Chloro-6-Aminopyrazine CAS#33332-28-4 Safety Information
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-41-22 |
| Safety Statements | 26-36/37/39-60-37 |
| TSCA | Yes |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
2-Chloro-6-Aminopyrazine CAS#33332-28-4 Product Application
2-Amino-6-chloropyrazine is an important nitrogen-containing heterocyclic compound widely used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a versatile building block for the preparation of various heterocyclic derivatives, pharmaceutical intermediates, and other specialty chemicals. Owing to its amino and chloro functional groups, the compound offers opportunities for further chemical modification and molecular derivatization, making it useful in the development of structurally diverse organic compounds. Its primary applications include laboratory research and development (R&D), medicinal chemistry studies, and various chemical and pharmaceutical production processes. With its distinctive pyrazine ring structure and synthetic versatility, 2-Amino-6-chloropyrazine plays a valuable role in pharmaceutical intermediate development, organic chemical synthesis, and related industrial research applications.
